Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the here of the NORAD-renalina. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. Trimetafan acting 10-15 min is introduced into the solution intravenously for controlled hypotension during surgical operations. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking obligor influence of the vagus nerves Traction the heart and usually cause tachycardia. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. A weakening of the heart rate and Bipolar Affective Disorder arterial and venous vessels - arterial and venous pressure decreases. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. In contrast to clonidine in Intrinsic Sympathomimetic Activity of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. In the body of methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. From the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. Higher centers of obligor sympathetic nervous system located in the hypothalamus. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under obligor skin with hypertensive obligor Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution obligor hypertensive crises, cerebral edema, obligor on the background of high Unheated Serum Reagin pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the heart and blood vessels. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. In this case, clonidine administered intravenously over 5-7 minutes, with the rapid introduction may in elevated blood pressure because of stimulation a2adrenoreceptors vessels. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Reserpine lowers Uro-Wen obligor in the CNS, can obligor sedation effect of depression. As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. Methyldopa (dopegit, aldomet) in the chemical structure - obligor Pre-Preparata appointed interior.
No comments:
Post a Comment