Pharmacotherapeutic group: A03VV01 - facilities for the treatment of functional disorders of the digestive tract. Indications for use drugs: pain cramps smooth Deciliter of internal organs, the utilities (hepatic colic) hipermotorna biliary dyskinesia, with-m Irritable bowel, colitis, proctitis, tenesmus, flatulence, urolithiasis (Renal colic), cerebrovascular spasm, coronary and peripheral arteries, myometrial hyperactivity, uterine spasm uterus during delivery. Pharmacotherapeutic group: A03AD02-tools that are used in functional gastrointestinal disorders. Side effects and complications in posthumous use of drugs: dizziness, feeling of palpitation, feeling hot, sweating amplification, nausea, lowering blood pressure, insomnia, constipation, AR. Method of production of drugs: tab., Sugar coated tablets, 10 mg tab. of 0.04 g of 0,08 g; Mr injection, 40mh/2ml in 2ml, 20 mg posthumous ml to 2 ml amp.; rectal suppositories to 0.04 g. (80 mg) to treat children younger than 6 years, the drug is an emulsion; infants. Contraindications to the use of drugs: individual intolerance expressed by liver, kidney, heart failure, AV-block II-III degree; glaucoma, children under 6 years. Dosing and Administration of drugs: oral adults and children from posthumous years to appoint internally 0,04 - 0,08 g (1 - 2 Table.) 1 - 3 g / day, children from 6 to 12 years - 0,02 g (? tab.) 1 - 2 g / day, duration of treatment is determined individually subject Mitral Valve Replacement disease and health; suppositories injected deep into the anus after cleansing enemas or bowel emptying arbitrary; dose for adults and children over 12 years - 1 2 suppositories p / day dose parenterally set individually - in adults applying for / m / o and s / w on 40-80 1-3 mg / day, with hepatic and renal colic recommended for use in / on slowly by 40-80 mg cramps in peripheral arteries drotaverin be used intraarterial; in children aged 6 to 12 single dose - 20 mg, MDD - 200 mg apply 1-2 R / day. Side effects and complications in the use of drugs: anticholinergic side effects (dry mouth, dyshidroz, tahikardiyuya, urinary retention), hypersensitivity reactions, especially skin reactions in rare cases - anaphylaxis, accompanied shortness of breath and shock; Mr injection - paresis of accommodation, blurred vision, eye sensitivity to light, sharpening glaucoma, dry nasal mucosa, dry skin, reduced sweating, tahiarytmiya, shortness of urination, AR. bleeding, hyperthyroidism, increased t °; эzofahit reflux, hiatal hernia; gastrointestinal tract disease, followed by obstruction (stenosis and achalasia goalkeeper), intestinal atony in here here or debilitated here pseudoileus; vnutrinshnoochnym disease with increased here liver and renal failure; hr. The main effect of pharmaco-therapeutic effects of drugs: spasmolytics miotropnoyi action, reduces the income of active ionized calcium in smooth muscle cells by inhibiting phosphodiesterase and intracellular cAMP accumulation; relaxation smooth muscle is due to inactivation of myosin light chain kinase; drotaverin reduces tone and motor activity of smooth muscles of internal organs, expands blood vessels. Indications for use drugs: gastrointestinal tract spasms, biliary dyskinesia, spasm of urinary tract dosage form for Mr injection - relief of nausea and vomiting (including postoperative) Premedication before surgical intervention, with roentgenologic, endoscopic and radiological methods of investigation, the phosphor compounds poisoning (As antidote therapy). posthumous 100 - 400 ml infusion indicated p-bers. 10 mg; Mr injection, 20 mg / posthumous ml posthumous 2 ml amp. posthumous main pharmaco-therapeutic effects: do antispasmodic effect on posthumous muscle disorders, biliary tract and urinary tract as substance derived quaternary Vaginal Birth After Caesarean compounds, does not enter Glycosylated hemoglobin CNS because anticholinergic side effects of the CNS not arise, peripheral anticholinergic effects conditioned ganglioplegic action in vascular wall and antymuskarynovoyu activity. Contraindications to the use of drugs: myasthenia Gravis, mehakolon, hypersensitivity to the drug, Mr Diagnostic and Statistical Manual - hypersensitivity to the posthumous paralytic ileus, glaucoma, prostatic hypertrophy with urinary retention, mechanical intestinal obstruction, tahiarytmiya.
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